REVIEWED BY
DR. NITA SHARMA DAS, PHD, ND, PHDHM, B
PHARM. on August 17, 2021
Written by ANDREW VON BUTZ, Natural Health Writer
EVIDENCE BASED
At first glance, you might mistake
it for an ordinary English
buttercup because of its
similar appearance., but the
Nigella sativa plant–which is actually the buttercup's more colorfully diverse,
healing cousin–remains one of the best kept botanical secrets of the Middle East that, chances are, is completely missing from your diet and lifestyle.
Locked inside
every flowering center of this attractive blooming annual are
precious seeds bearing a nutritive oil so amazing that more than 1,000 peer-reviewed studies (and counting!) have contributed to the revelatory
tapestry of what we now know to be its virtually limitless therapeutic
potential (as per search result found in PubMed by using the search term nigella sativa, https://www.ncbi.nlm.nih.gov/pubmed/?term=nigella+sativa)
This cherished
elixir is commonly
referred to as black cumin oil– or what you might refer to as the "lifeblood" of nigella sativa seeds.
When the flower
pods in which these seeds live reach their full maturity and open up,
the initial pale color they reveal quickly darkens into a uniquely
iconic shade of black.
This is right about the time when nigella sativa
seeds are ready to be harvested and pressed, releasing what you'll soon find out is one of the most powerfully restorative functional foods on the planet–and one that many people, especially in the West, have yet to even discover.
Black cumin oil: a historical treasure
Hailing from the Ranunculaceae family of plants, Nigella sativa
bears a rich history
of use in ancient
medicinal systems including Tibetan, Unani, Siddha and Ayurveda. [1]
. Its popularity spans a multitude of cultures, religious systems, and eras, with historical records
showing that both the seeds and the oil
of the precious plant have long been prized items in the Arab trade.
Because of their many miraculous
properties, these botanical treasures have made their way far beyond the borders of countries like Iran and Turkey where Nigella sativa grows natively, and into whole new continents
like Asia, Africa, and Europe–and perhaps
most recently, North America. [2]
The earliest
known literary reference
to Nigella sativa just so happens to be in the Old Testament book of Isaiah,
where it is referred to in the Hebrew tongue
as "ketzah." The ancients of this
early Biblical epoch are noted as having baked black cumin oil into various breads and cakes in order
to procure these foods with its unique
flavor and healing profile.
In Isaiah
28:25,27, this biblical prophet contrasts the process of harvesting Nigella sativa
seeds to that of traditional wheat, explaining how
rather than being threshed like typical grains, the seeds of Nigella sativa were instead beaten out of the plant using a stick or rod. [3]
In the Islamic tradition, the prophet Muhammed
is credited as having
defined black cumin oil as a miraculous healing panacea that he believed
is fully capable of curing
almost any ailment.
Religious
records indicate that he gave specific instruction to his followers to "hold on to the use of the black seed (black
seed being another common name for black cumin), for indeed it has a remedy for every disease
except death." [4]
Though neither religion
had the scientific wherewithal at the time to support
such claims the way we do now, these ancients recognized from the common cultural
and religious uses of black cumin oil that the substance is,
indeed, something quite special.
And it was only a matter of time before black cumin oil eventually
made its way into Assyrian herbal literature and other early medical publications, only to continue from there earning
a formidable reputation as one of the world's most distinctive "super foods."
What makes black cumin
oil so special? A quick primer
Widely considered to be the father of modern medicine, the Greek physician Hippocrates was among the first
to categorically identify black cumin oil's specific
health benefits. He discovered, for instance, that taking it can help to soothe the stomach and address liver disorders.
He and his fellow healers also observed that black cumin oil is effective in
promoting skin health, as well as boosting immunity and normalizing inflammation levels–hence why black cumin oil was later added to the renowned
German medicinal plants encyclopedias that were published between
the 16th and 18th centuries. [3]
In more modern
times, peer-reviewed science has uncovered even
greater details and specifics into the therapeutic efficacy of black cumin oil. We now know, for example, that Nigella sativa seeds and their precious
oil are helpful in addressing everything from nervous system disorders and gastrointestinal imbalances to respiratory ailments and
even "the big C:" cancer. [1]
In his famous work The Canon of Medicine, Islamic philosopher Ibn Sina further wrote about how
black cumin oil can help promote purification through detoxification. He
noted that black cumin oil
directly contributes to improving lung function, balancing the body's immune
response, and improving overall wellbeing. [5]
All of this and more can be attributed
to black cumin oil's impressive nutrient profile–perhaps the most noteworthy
of which is its dense array
of essential fatty acids. These include those of the polyunsaturated variety
that is known to help the body produce more prostaglandin E1, a hormone-like fatty acid that's directly associated
with immune system regulation, sugar metabolism,
skin health, and blood circulation. Prostaglandin E1 is also said to play a vital role in helping to protect the mucosal lining of the stomach
against damage and degradation. [6]
What's more, protocols of medicine from both Eastern
and Western traditions now
recognize these and many other potential health benefits arising from the use of black cumin oil. Almost every system of medicine
throughout history, in fact–from traditional Ayurveda and Unani in the Far East to contemporary integrative, and "alternative" medicine
systems of the West–has shown an
appreciation for at least something that black cumin oil has to offer in terms of functional therapeutics. [1]
What modern science
has to say about
black cumin oil as
a viable therapeutic
Since the gold standard of contemporary, science-based medicine is the peer-review process,
you're probably curious
about how black cumin oil as a therapeutic stack up in terms of meeting
the rigorous scientific standards of today. Well, you'll be pleased
to know that Nigella sativa currently ranks among the most extensively studied plant species in the world.
[1]
Furthermore, it's
pharmacological potential is so immensely vast that it'll likely remain the subject of intense scientific scrutiny well into the foreseeable future–not to mention the fact that science
has likely only just begun to scratch the surface in uncovering everything its full potential.
Based on what we already know, though,
it's safe to say that Nigella sativa
is nothing short of a "wonder" food when it comes
to its ability to improve
lives and support
sustained wellness. There are,
in fact, different health conditions that are
known to benefit from using black cumin oil–its various
constituents performing more than 20 distinct pharmacological actions
throughout the body. [1]
A comprehensive review of some of the latest science
on Nigella sativa that was published in the Asian Pacific Journal of Tropical Biomedicine back in 2013 [1] reveals these to include black cumin oil's effective use as a:
·
Diuretic (increases urine production)
·
Anti-hypertensive (lowers blood pressure)
·
Anti-diabetic (lowers blood sugar)
·
Anti-cancer
·
Immunomodulatory (balances immunity)
·
Analgesic (kills pain)
·
Anti-microbial
·
Anthelmintics (kills parasites)
·
Anti-inflammatory
·
Spasmolytic
(relaxes muscles)
·
Bronchodilator (opens air passageways)
·
Gastro protective
·
Hepatoprotective (protects liver)
·
Renoprotective (protects kidneys)
·
Antioxidants
[1]
Other research
has further identified black cumin oil as helping in these additional
areas as well:
· Anti-bacterial
·
Anti-ulcerative
·
Anti-cholinergic (modulates nervous system)
·
Anti-fungal
·
Anti-viral
·
Interferon-inducing (boosts immunity)
·
Leukotriene-antagonizing (supports
healthy respiration)
·
Tumor necrosis factor
alpha-inhibiting (fights cancer)
[1]
If you were to sum it all up
in one word, energizing would probably be the best adjective to describe black cumin oil's comprehensive mechanistic
action in supporting bodily health. Islamic medicine to this very day regards it as a full-spectrum stimulant–though not in the coffee-drinking sense, but rather as a nutrient-based, metabolic motivator that helps the body
to more optimally function
in both an effective and efficient state.
Phytochemicals:
one of the secrets behind black
cumin oil's incredible efficacy
While there are
a number of unique compounds locked away inside black cumin oil that contribute to its profound therapeutic efficacy, there's one
compound in particular that science has pinpointed
as holding exceptional promise: thymoquinone. Also known as TQ, this powerful substance probably has
the most extensive track record of investigatory focus when it comes
to scientific research: and for good reason.
[1]
Since at least
the 1960s, researchers have been progressively uncovering how TQ works to scavenge and neutralize damaging free radicals that cause disease, as well
as to counteract chronic inflammation
and eliminate cancer cells (among other important functions). Research published
in the journal Biochemical Pharmacology, for instance,
reveals that multiple disease models show
benefits from the clinical application of TQ, including in the treatment of encephalomyelitis (inflammation of the brain and spinal
cord), diabetes, asthma, and carcinogenesis. [7]
It is now becoming
widely understood that inflammation is a primary
factor in the formation of many chronic
illnesses. And TQ's role in an address this is critical, as the
substance blocks oxidative
damage while preserving and supporting the function of antioxidant
enzymes like catalase, glutathione peroxidase, and glutathione-S-transferase that support longevity. The
anti-cancer benefits of TQ are further noteworthy, as research shows that it helps
to prevent cancer cells from spreading and reproducing, as well as provokes cancer cells to "commit suicide" (apoptosis). [8]
TQ isn't alone in this, however.
There are multiple
other phytochemical compounds
contained in black cumin oil that contribute even further to fighting off disease. Combination of chemical constituents of Nigella sativa gives a synergistic property.
[9]
Similar to thymoquinone, thymohydroquinone is another compound
in black cumin oil that's generally regarded as one of the world's most potent natural
acetylcholinesterase (AChE) inhibitors. [10] AChE inhibitors prevent the breakdown
of acetylcholine, the body's
primary neurotransmitter that plays a critical role in the function of both the peripheral and central nervous
systems. The body's motor neurons release acetylcholine in order to activate muscles,
for instance.
Acetylcholine is
also required by the body and brain to support learning, attention span, arousal, motivation, and memory.
[11]
Synthesized AChE
inhibitors are often prescribed to patients with serious brain conditions like dementia, as their purpose is to prevent the breakdown of chemicals that
serve as brain fuel. This suggests that black cumin oil, which is naturally
rich in AChE inhibiting
substances, may be used as a natural alternative for addressing conditions like Alzheimer's disease,
autism, schizophrenia,
Parkinson's disease, myasthenia gravis (muscular weakness), postural tachycardia syndrome (blood disorder), and various
other neurodegenerative health conditions. [10]
Science-based uses of black cumin
oil for specific health conditions
Incorporating black cumin oil into
your life can be as
simple as using it like you would
olive, hemp, or any other nutritive food oil.
You can pour it over salad, mix it into yogurt, bake it into your favorite
bread, or even just eat it by the spoonful. Topical applications
of black cumin oil can similarly help to restore and moisturize skin or nourish and thicken hair. There are also a variety
of specific medical applications involving black cumin oil that have strong scientific backing,
including for the following uses:
Stop superbugs in their tracks. Research out of Pakistan
determined that black cumin oil is an effective remedy for Methicillin resistant Staphylococcus
aureus, or MRSA, one of the deadliest
"superbugs" in the world. [12] Prepared
extracts of black cumin oil have
shown similar efficacy in eradicating another type of deadly infection
known as Helicobacter pylori–working just as effectively as conventional triple eradication therapy. [13]
Get rid of those
nasty toxins. Scientists
from Egypt found that black cumin oil functions as a powerful
protector against hepato- renal toxicity, meaning
it helps the liver to
rid the body of harmful chemical toxins. Measures of various oxidative
stress markers both before and after black cumin oil was introduced in tests revealed that this incredible super food
helped to improve levels of
toxin-eliminating enzymes while reducing others associated with disease and liver breakdown.
[14]
Keep your blood sugar in check.
Type-2 diabetics can benefit from consuming black cumin oil, which was found in a Saudi Arabian study to help improve blood sugar levels in patients suffering from
metabolic disorders. Taking just two grams of black cumin oil per day showed effectiveness in reducing fasting
glucose levels, decreasing insulin resistance, increasing beta-cell function, and reducing glycosylated
hemoglobin (HbA1c) levels. [15]
Achieve your ideal weight. If too much fat and not enough muscle is getting you down, consider the
fact that research out of Iran found that black cumin oil possesses unique anti-obesity properties. [16] Individuals who consume it regularly
have a decreased
risk of other obesity-related health conditions such as heart disease. [16, 17]
No more seizures. Individuals with epilepsy may find relief from taking black cumin oil if the results of a
double-blinded crossover clinical trial, also
out of Iran, are any indication.
Tests on human patients revealed that black cumin oil has
powerful anticonvulsant effects that can help to reduce
both the frequency
and intensity of seizure episodes, particularly in children. [18]
Improve the quality
of your hair and skin. Besides
just adding shine to hair and glow to the skin, black cumin oil offers added benefits
that support the fundamental health of these two important structures of the body. Research shows that hair loss, for instance,
can actually be reversed by incorporating black cumin oil into
one's beauty regimen. [19]
Skin conditions may also disappear
from its use, as researchers from Iran found
that black cumin oil works at least as good as the popular skin cream betamethasone (topical steroid) at
decreasing the severity of hand eczema. [20]
Breathe full and
clear. Patients with asthma or
other related respiratory conditions
can similarly benefit from taking black cumin oil. One animal model
found that thymoquinone (TQ) in the oil works better than the drug fluticasone (Flonase) at targeting both allergic
reactions and asthmatic symptoms. [21]Human trials have likewise demonstrated
the ability of black cumin oil to help clear the air passageway for better breathing. [22]
Sore throat:
be gone. Acute tonsillopharyngitis and other inflammatory conditions of the
throw were shown in a paper
out of Indonesia to respond positively to the use of black cumin oil.
This double-blind, placebo-controlled
study revealed that taking just 360 milligrams of Nigella sativa extract along with 50 milligrams of Phyllanthus
niruri (a tropical healing plant) resulted in substantial reductions in throat pain, as well as
enhanced healing. [23]
Clear
out all that lung pollution. Water-based extracts of Nigella- sativa were found in yet another
Iranian study to counteract the damaging effects
that chemical weapons
have on the lungs.
While not everyone in the world is exposed to such wartime weapons,
the findings extrapolate well to other forms of "lung pollution," as black seed compounds
were shown to reduce chest wheezing
while improving pulmonary function, all without the need for any additional drug treatments. [24]
Kick that addiction. There's been a lot of talks recently about the opioid epidemic and the widespread problem of addiction in many parts of the world. Well, black cumin oil can help with that, too! Taking just 500 milligram increments
of Nigella sativa on a regular
basis, researchers from Pakistan have found, is highly effective in helping opioid addicts to kick the habit. Not only did black cumin oil show efficacy in
minimizing withdrawal symptoms, but it also
demonstrated powerful appetite-inducing effects. [25]
What cancer? Scientists in Croatia found that multiple
phytochemicals in black cumin oil, including the aforementioned TQ and thymohydroquinone, are so powerfully anti-cancer in nature that they can help reduce
the number of circulating tumor cells in a patient by up to 52 percent. [26] Another study involving
rats found that Nigella sativa extract works just as well, [27] and enhance the chemopreventive effect of 5-fluorouracil at suppressing the growth of colon cancer cells specifically–and can be used as adjuvant
therapy with many chemotherapeutic agents. It has been observed
that combination of TQ with synthetic chemotherapeutic agent exerts less toxicity
and reduce side effects. . These anti-tumor properties extend beyond just colon cancer to cancers of the prostate,
pancreas, and lungs, yet another
study found. [28]
At Kimmel Cancer University they were able to kill 80% of Pancreatic Cancer Tumors.
ACTIVATION PERFECT PRESS BLACK SEED OIL - BUY HERE
Choosing the best quality black cumin oil
When choosing
which type of black cumin oil
to purchase, it's important to pay
close attention to a product's purity, processing, and packaging.
You'll want
to stick with cold-pressed varieties of black cumin oil that are processed without the use of heat or noxious chemicals, both of which can damage or disrupt
the nutrients that naturally exist in delicate
complexity and perfect balance within pure, freshly-pressed oil. [29]
This means also choosing
varieties that are labeled as being 100% pure "black seed oil" or
"black cumin oil," without any outside
fillers or additives.
References :
- Aftab Ahmad, Asif Husain, Mohd Mujeeb, Shah Alam Khan, Abul
Kalam Najmi, Nasir Ali Siddique,
Zoheir A. Damanhouri, Firoz Anwar. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac
J Trop Biomed. 2013 May; 3(5): 337–352. doi: 10.1016/S2221-1691(13)60075-1. Online available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/
- Amin F. Majdalawieh, Muneera W. Fayyad. Recent advances on the
anti- cancer properties of
Nigella sativa, a widely used food additive. J
Ayurveda Integr Med. 2016 Jul-Sep;
7(3): 173–180. Published online
2016 Sep 17. doi: 10.1016/j.jaim.2016.07.004. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052360/
- History of Nigella sativa; Retrieved from
https://theblessedseed.com/history-of- black-seed/
- Mohammad Tariq. Nigella Sativa Seeds:
Folklore Treatment in Modern Day Medicine. Saudi J Gastroenterol. 2008 Jul; 14(3): 105–106. doi: 10.4103/1319- 3767.41725. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702918/
- Khan FA. Approaching modern technological challenges through
the traditions of Ibn Sīnā (980–1036) J Islam Med Assoc. 2008;40:15–22. http://dx.doi.org/10.5915/40-1-5280.
- Black Seeds "A cure for every disease except
death." (Sahih Bukhari); Retrieved from https://www.missionislam.com/health/blackseed.html
- Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders
and cancer. Biochem Pharmacol. 2012 Feb 15;83(4):443-51.
doi: 10.1016/j.bcp.2011.09.029. Epub 2011 Oct 10. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22005518
- Hayes JD, Pulford DJ. The
glutathione S-transferase supergene family:
regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 1995;30(6):445-600. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8770536
- Fatemeh Forouzanfar, Bibi Sedigheh Fazly Bazzaz, Hossein Hosseinzadeh. Black cumin (Nigella sativa) and its constituent (thymoquinone): a review
on antimicrobial effects. Iran J Basic Med Sci. 2014 Dec; 17(12): 929–938. Retrieved
from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387228/
- Mohammad Reza Khazdair. The Protective Effects of
Nigella sativa and Its Constituents on Induced
Neurotoxicity.
J Toxicol. 2015;
2015: 841823.
Published online 2015 Oct 29. doi: 10.1155/2015/841823. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641935/
- Maria Isabel Miranda. Chapter 7Changes in Neurotransmitter
Extracellular Levels during
Memory Formation. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK3921/
- Hannan A, Saleem S, Chaudhary S, Barkaat M, Arshad MU. Anti bacterial activity
of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus. J Ayub Med Coll Abbottabad. 2008 Jul-Sep;20(3):72-4. Retrieved
from https://www.ncbi.nlm.nih.gov/pubmed/19610522 Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman
- RM, Randhawa MA.
Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients
with non-ulcer dyspepsia.
Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. doi: 10.4103/1319-3767.65201.Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20616418
- Hamed MA, El-Rigal NS, Ali SA. Effects of black seed oil on resolution of hepato-renal
toxicity induced bybromobenzene in rats. Eur Rev Med Pharmacol Sci. 2013 Mar;17(5):569-81. Retrieved
from https://www.ncbi.nlm.nih.gov/pubmed/23543440
- Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A. Effect of
Nigella sativa seeds on the glycemic control of patients
with type 2 diabetes mellitus. Indian J Physiol Pharmacol. 2010
Oct-Dec;54(4):344-54. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21675032
- Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M. A
systematic review of anti- obesity medicinal plants - an update. J Diabetes Metab Disord. 2013 Jun 19;12(1):28. doi: 10.1186/2251-6581-12-28. Retrieved
from https://www.ncbi.nlm.nih.gov/pubmed/23777875
- Seyed MohammadMousavi, AliSheikhi, Hamed KordVarkaneh, MeysamZarezadeh, JamalRahmani, AlirezaMilajerdi, Effect of Nigella sativa supplementation on obesity indices: A systematic
review and meta-analysis of
randomized controlled trials. Complementary Therapies
in Medicine Volume 38, June 2018, Pages 48-. d.o.i https://doi.org/10.1016/j.ctim.2018.04.003. Retrieved
from https://www.sciencedirect.com/science/article/pii/S0965229918300785
- Akhondian J, Parsa A, Rakhshande H.
The effect of Nigella sativa L. (black cumin
seed) on intractable pediatric seizures. Med Sci Monit. 2007 Dec;13(12):CR555-9. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18049435
- Ahmad M. Eid, Nagib A. Elmarzugi, Laila M. Abu
Ayyash, Maher N. Sawafta, Hadeel I. Daana. A Review
on the Cosmeceutical and External
Applications of Nigella sativa. J Trop Med. 2017;
2017: 7092514. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735686/
- Yousefi M, Barikbin B, Kamalinejad M, Abolhasani E, Ebadi A, Younespour S, Manouchehrian M, Hejazi S. Comparison
of therapeutic effect of topical Nigella with Betamethasone and Eucerin in
hand eczema. J Eur Acad Dermatol Venereol. 2013 Dec;27(12):1498-504.
doi: 10.1111/jdv.12033. Epub 2012 Dec 1. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23198836
- Keyhanmanesh R, Boskabady MH, Eslamizadeh MJ, Khamneh S, Ebrahimi MA. The effect of thymoquinone, the main constituent of Nigella sativa on
tracheal responsiveness and white blood cell count in lung lavage of
sensitized guinea pigs. Planta Med. 2010 Feb;76(3):218-22. doi: 10.1055/s-0029-1186054. Epub 2009 Aug 26. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19711253
- Boskabady MH, Mohsenpoor N, Takaloo L.
Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010 Aug;17(10):707-13.doi:10.1016/j.phymed.2010.01.002. Epub 2010 Feb
10. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20149611
- Dirjomuljono M, Kristyono I, Tjandrawinata RR, Nofiarny D.
Symptomatic treatment of acute tonsillo-pharyngitis patients
with a combination of Nigella sativaand Phyllanthus niruri extract. Int J Clin Pharmacol Ther. 2008 Jun;46(6):295-306. Retrieved
from https://www.ncbi.nlm.nih.gov/pubmed/18541126
- Boskabady MH, Farhadi J. The possible prophylactic effect of Nigella sativa seed
aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a
randomized, double-blind, placebo-controlled
trial. J Altern Complement Med. 2008 Nov;14(9):1137-44. doi: 10.1089/acm.2008.0049. Retrieved
from https://www.ncbi.nlm.nih.gov/pubmed/18991514
- Sangi S, Ahmed SP, Channa MA, Ashfaq M, Mastoi SM. A new and
novel treatment of opioid
dependence: Nigella sativa 500 mg. J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):118-24. Retrieved
from https://www.ncbi.nlm.nih.gov/pubmed/19385474
- Ivankovic S, Stojkovic R, Jukic M, Milos M, Milos M, Jurin M. The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo. Exp Oncol. 2006 Sep;28(3):220-4. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17080016
- Salim EI, Fukushima S. Chemopreventive
potential of volatile oil from black cumin (Nigella
sativa L.) seeds against rat colon carcinogenesis. Nutr Cancer. 2003;45(2):195-202. Retrieved
from https://www.ncbi.nlm.nih.gov/pubmed/12881014
- A.G.M. Mostofa, Md Kamal Hossain, Debasish Basak, Muhammad Shahdaat Bin Sayeed. Thymoquinone as a
Potential Adjuvant Therapy for Cancer Treatment: Evidence
from Preclinical Studies. Front Pharmacol.
2017; 8:295. Published online 2017 Jun 12. doi:
10.3389/fphar.2017.00295. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466966/
- Nameer Khairullah Mohammed,
Mohd Yazid Abd Manap, Chin Ping Tan, Belal J. Muhialdin, 1Amaal M. Alhelli, Anis Shobirin Meor Hussin. The Effects of Different Extraction Methods
on Antioxidant Properties, Chemical Composition, and Thermal Behavior
of Black Seed (Nigella sativaL.) Oil. Evid Based Complement Alternat Med. 2016; 2016: 6273817.
Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015008/
- Muhammad Safwan Ahamad
Bustamam, Kamarul Arifin Hadithon, Ahmed Mediani, Faridah Abas, Yaya Rukayadi, Nordin Lajis, Khozirah Shaari, Intan Safinar Ismail. Stability Study of
Algerian Nigella sativa Seeds Stored
under Different Conditions. J Anal Methods Chem. 2017; 2017: 7891434.
Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309406/
